Trusted, medically reviewed health information • Not a substitute for medical advice
Medically Verified MonographRxClass: Xanthine Oxidase Inhibitor

Allopurinol

Generic Name: Allopurinol

Common Brand Names: Zyloprim
Dosage Form:Tablet
Route:Oral
Pregnancy Category:C
Last Reviewed:9/21/2026

Seek Urgent Medical Attention If:

You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.

Uses & Medical Indications

Prevent gout attacks

Medical Conditions Treated:

Gout, hyperuricemia

Dosage & Administration Guidelines

Adult Dosage

100-300 mg daily

Pediatric Dosage

N/A

Elderly / Geriatric Considerations

Start low, adjust for renal function

Maximum Dose Limit

800 mg/day

Renal Impairment:

Reduce dose based on CrCl

Hepatic Impairment:

Use with caution

Side Effects & Safety Warnings

Common Side Effects

Rash, nausea

Serious Adverse Reactions

Severe skin reactions, hepatotoxicity

Contraindications:

Hypersensitivity

Important Warnings & Precautions:

Discontinue at first sign of rash

Interactions (Drugs, Food & Alcohol)

Drug-Drug Interactions:

Azathioprine, Mercaptopurine

Food & Dietary Interactions:

N/A

Alcohol Interaction Warning:

Limit, can increase uric acid

Pregnancy & Breastfeeding Safety

Pregnancy Safety

Use if benefit outweighs risk

Breastfeeding / Lactation

Compatible

Patient Counseling & Practical Advice

How to Take:

Drink plenty of fluids

What to Do if You Miss a Dose:

Take as soon as remembered

Recommended Monitoring & Lab Tests:

Serum uric acid

Trustworthy Sources & Medical Review

Content for Allopurinol was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:

  • Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
  • World Health Organization (WHO) — Model List of Essential Medicines 23rd List
  • Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
  • National Health Service (NHS) — Medicines A to Z Clinical Guidelines
Reviewer Credentials: PharmD, Clinical PharmacologistLast Reviewed Date: 9/21/2026

The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.