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Trusted, medically reviewed health information • Not a substitute for medical advice
Important: The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Generic Name: Ciprofloxacin Hydrochloride
Sudden tearing chest or back pain (aortic dissection), seizures, acute anaphylaxis.
Complicated urinary tract infections, pyelonephritis, infectious bacterial diarrhea, typhoid fever, intra-abdominal infections, bone and joint infections, and anthrax post-exposure prophylaxis.
Pyelonephritis, Complicated UTI, Infectious Diarrhea, Typhoid Fever, Prostatitis
Uncomplicated UTI: 250 mg to 500 mg every 12 hours for 3 days. Complicated UTI / Pyelonephritis: 500 mg every 12 hours for 7 to 14 days. Severe systemic/bone infection: 500 mg to 750 mg every 12 hours.
Generally restricted due to potential arthropathy; approved for complicated UTI/pyelonephritis in children 1-17 years: 10 to 20 mg/kg every 12 hours (max 750 mg/dose).
Dose based on renal clearance (eGFR).
1500 mg daily orally.
eGFR 30-50 mL/min: 250-500 mg every 12 hours. eGFR <30 mL/min: 250-500 mg every 18-24 hours.
No dosage adjustment required.
Nausea, diarrhea, dyspepsia, headache, dizziness, mild restlessness.
Tendon rupture (especially Achilles tendon), peripheral neuropathy, CNS toxicities (seizures, psychosis), aortic aneurysm rupture, QT prolongation, myasthenia gravis exacerbation.
History of fluoroquinolone-induced tendon rupture, concurrent administration with Tizanidine, myasthenia gravis.
FDA Black Box Warning: Fluoroquinolones are associated with disabling and potentially irreversible serious adverse reactions including tendinitis, tendon rupture, peripheral neuropathy, and CNS effects. Avoid in uncomplicated infections if other options exist.
Antacids containing Al/Mg, Iron, Sucralfate, Calcium (chelation inhibits absorption), Theophylline, Warfarin, Methotrexate.
Do not take with dairy products (milk, yogurt) or calcium-fortified juices alone; food reduces chelation if part of a balanced meal.
Avoid alcohol; additive central nervous system dizziness and impairment.
Markedly reduced gastrointestinal absorption of Ciprofloxacin resulting in clinical treatment failure.
Marked enhancement of anticoagulant effect with sudden spikes in INR and severe hemorrhage.
Generally avoided during pregnancy due to cartilage damage observed in animal studies; reserved for multidrug-resistant infections with no alternatives.
Compatible in short courses; monitor infant for loose stools or thrush.
Drink plenty of fluids while taking ciprofloxacin to avoid crystal formation in urine. Stop taking the medication and call your doctor immediately if you feel pain, swelling, or popping in your tendons (like the back of your ankle).
Take as soon as remembered if more than 6 hours before next dose.
Clinical response; watch for tendon pain or swelling, numbness, or tingling in extremities.
Content for Ciprofloxacin was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:
The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.