Trusted, medically reviewed health information • Not a substitute for medical advice
Medically Verified MonographPrescription, OTCClass: Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Naproxen

Generic Name: Naproxen

Common Brand Names: Aleve, Naprosyn, Anaprox
Dosage Form:Tablet, Capsule, Oral Suspension
Route:Oral
Pregnancy Category:C (prior to 30 weeks), D (starting at 30 weeks)
Last Reviewed:9/21/2026

Seek Urgent Medical Attention If:

You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.

Uses & Medical Indications

Relief of mild to moderate pain, inflammation, and fever

Medical Conditions Treated:

Osteoarthritis, Rheumatoid Arthritis, Dysmenorrhea, Gout, Pain

Dosage & Administration Guidelines

Adult Dosage

250-500 mg twice daily

Pediatric Dosage

10 mg/kg/day in two divided doses (JRA)

Elderly / Geriatric Considerations

Use lowest effective dose

Maximum Dose Limit

1500 mg/day for short-term; 1000 mg/day chronic

Renal Impairment:

Not recommended if CrCl < 30 mL/min

Hepatic Impairment:

Use caution; lower dose recommended

Side Effects & Safety Warnings

Common Side Effects

Dyspepsia, abdominal pain, nausea, headache, edema

Serious Adverse Reactions

GI ulceration/bleeding, MI, stroke, renal failure

Contraindications:

CABG surgery setting, history of asthma/urticaria after NSAIDs

Important Warnings & Precautions:

Cardiovascular risk, GI risk

Interactions (Drugs, Food & Alcohol)

Drug-Drug Interactions:

Anticoagulants, ACE inhibitors, diuretics, lithium, SSRIs

Food & Dietary Interactions:

Take with food or milk to minimize GI upset

Alcohol Interaction Warning:

Increases risk of GI bleeding

Pregnancy & Breastfeeding Safety

Pregnancy Safety

Avoid at 30 weeks gestation and later

Breastfeeding / Lactation

Excreted in human milk; avoid if possible

Patient Counseling & Practical Advice

How to Take:

Take with food. Do not take other NSAIDs concurrently.

What to Do if You Miss a Dose:

Take as soon as remembered. Skip if close to next dose.

Recommended Monitoring & Lab Tests:

Pain relief, CBC, chemistry profile, BP

Related Medicines in Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Trustworthy Sources & Medical Review

Content for Naproxen was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:

  • Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
  • World Health Organization (WHO) — Model List of Essential Medicines 23rd List
  • Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
  • National Health Service (NHS) — Medicines A to Z Clinical Guidelines
Reviewer Credentials: PharmD, Clinical PharmacologistLast Reviewed Date: 9/21/2026

The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.