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Medically Verified MonographPrescriptionClass: Combination Oral Contraceptive (Progestin/Estrogen)

Yaz

Generic Name: Drospirenone and Ethinyl Estradiol

Common Brand Names: Yaz, Gianvi, Loryna
Dosage Form:Oral Tablets (24 active / 4 inert)
Route:Oral
Pregnancy Category:Category X
Last Reviewed:9/21/2026

Seek Urgent Medical Attention If:

You experience severe allergic reaction symptoms (swelling of the face, lips, tongue, or throat causing difficulty breathing), severe rash with skin peeling, sudden intense chest pain, or symptoms of overdose. Call emergency medical services immediately.

Uses & Medical Indications

Prevention of pregnancy; treatment of symptoms of premenstrual dysphoric disorder (PMDD); treatment of moderate acne vulgaris in females >= 14 years.

Medical Conditions Treated:

Oral Contraception, Premenstrual Dysphoric Disorder (PMDD), Moderate Acne Vulgaris

Dosage & Administration Guidelines

Adult Dosage

One tablet orally daily at the exact same time every day for 28 consecutive days.

Pediatric Dosage

Approved for post-menarche females under healthcare supervision.

Elderly / Geriatric Considerations

Not indicated in postmenopausal women.

Maximum Dose Limit

1 tablet daily.

Renal Impairment:

Contraindicated in renal impairment due to drospirenone's antimineralocorticoid properties.

Hepatic Impairment:

Contraindicated in acute or severe hepatic disease.

Side Effects & Safety Warnings

Common Side Effects

Nausea, breast tenderness, breakthrough bleeding, headache, mood swings.

Serious Adverse Reactions

Venous thromboembolism (DVT/PE), arterial thromboembolism (stroke, MI), hyperkalemia, gallbladder disease.

Contraindications:

Smokers >35 years, deep vein thrombosis history, breast cancer, uncontrolled hypertension.

Important Warnings & Precautions:

Black Box Warning: Cigarette smoking increases risk of serious cardiovascular events in women over 35.

Interactions (Drugs, Food & Alcohol)

Drug-Drug Interactions:

Drugs that increase serum potassium (ACE inhibitors, ARBs, potassium-sparing diuretics), CYP3A4 inducers (St. John's wort, rifampin).

Food & Dietary Interactions:

Avoid excessive potassium intake.

Alcohol Interaction Warning:

No direct chemical interaction.

Pregnancy & Breastfeeding Safety

Pregnancy Safety

Contraindicated in verified pregnancy; discontinue if pregnancy is confirmed.

Breastfeeding / Lactation

May decrease breast milk volume; not recommended until weaning.

Patient Counseling & Practical Advice

How to Take:

Take at the exact same time every single day. Do not smoke while taking this medication.

What to Do if You Miss a Dose:

Follow package instructions strictly regarding missed pill rules and use backup contraception.

Recommended Monitoring & Lab Tests:

Blood pressure, serum potassium during first month if taking concurrent potassium-raising drugs.

Trustworthy Sources & Medical Review

Content for Yaz was synthesized and fact-checked against standardized regulatory monographs, official pharmacopoeias, and national health authorities:

  • Central Drugs Standard Control Organization (CDSCO) — National List of Essential Medicines
  • World Health Organization (WHO) — Model List of Essential Medicines 23rd List
  • Indian Pharmacopoeia Commission (IPC) — Indian Pharmacopoeia Drug Monographs
  • National Health Service (NHS) — Medicines A to Z Clinical Guidelines
Reviewer Credentials: PharmD, Clinical PharmacologistLast Reviewed Date: 9/21/2026

The information provided on this website is for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.